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根據(jù)表觀遺傳時鐘，HIV-1感染會加速衰老

2022.06.11 貴州

HIV-1 Infection Accelerates Age According to the Epigenetic Clock

|核心內(nèi)容：

背景：1型人類免疫缺陷病毒(HIV)感染與加速衰老的臨床癥狀有關(guān)，表現(xiàn)為年齡相關(guān)疾病在相對年輕時發(fā)病率和多樣性的增加，這也得到了器官和細胞病理分析的支持。但現(xiàn)階段很難在分子水平上檢測或量化加速衰老效應(yīng)。

方法：在這里，我們使用一種基于宿主DNA甲基化水平的表觀遺傳衰老生物標記物來研究HIV感染導(dǎo)致的加速衰老效應(yīng)。通過Illumina Infinium甲基化450K平臺檢測腦組織和血液組織中的DNA。

結(jié)果：使用6個新的DNA甲基化數(shù)據(jù)集，我們發(fā)現(xiàn)HIV感染導(dǎo)致腦組織(7.4歲)和血液(5.2歲)表觀遺傳年齡的增加。雖然在血液中觀察到的加速衰老效應(yīng)可能反映了血細胞成分的變化(特別是耗盡的細胞毒性T細胞)，但對觀察到的腦組織加速衰老效應(yīng)的解釋還不太清楚。

結(jié)論：總體而言，我們的結(jié)果表明，表觀遺傳時鐘是檢測HIV感染引起的加速衰老效應(yīng)的有用生物標記物。這個工具可以用來準確地評估單個組織和細胞的年齡加速程度。

HIV感染增加了血液的表觀遺傳年齡

原文：

BACKGROUND: Infection with human immunodeficiency virus type 1 (HIV) is associated with clinical symptoms of accelerated aging, as evidenced by the increased incidence and diversity of age-related illnesses at relatively young ages and supporting findings of organ and cellular pathologic analyses. But it has been difficult to detect an accelerated aging effect at a molecular level.

METHODS: Here, we used an epigenetic biomarker of aging based on host DNA methylation levels to study accelerated aging effects due to HIV infection. DNA from brain and blood tissue was assayed via the Illumina Infinium Methylation 450 K platform.

RESULTS:Using 6 novel DNA methylation data sets, we show that HIV infection leads to an increase in epigenetic age both in brain tissue (7.4 years) and blood (5.2 years). While the observed accelerated aging effects in blood may reflect changes in blood cell composition (notably exhausted cytotoxic T cells), it is less clear what explains the observed accelerated aging effects in brain tissue.

CONCLUSIONS: Overall, our results demonstrate that the epigenetic clock is a useful biomarker for detecting accelerated aging effects due to HIV infection. This tool can be used to accurately determine the extent of age acceleration in individual tissues and cells.

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